Effectiveness of antihypertensive agents in stage I/II hypertensive patients with ace (I/D) gene polymorphism

نویسندگان

چکیده

Background: Angiotensin converting enzyme (ACE) is the key enzyme, regulates blood pressure which encoded by 21kb gene that consists of 26 exons and located on chromosome 17, contains a polymorphism in form either Insertion (I) or Deletion (D). The aim was to study effect antihypertensive drugs patients essential hypertension associated with ACE polymorphism. Methods: Hypertensive were recruited followed genetic test done for detecting polymorphism, then divided as Group-A & B. Group –A B treated atenolol (25mg) azilsartan (40 mg) three months respectively. Results: Systolic diastolic recorded both groups before after commencement treatment. Among 88 newly diagnosed hypertension, majority population belongs genotype D/D (38.63%) I/D (31.81%) II (29.54%) genotype. Significant difference found systolic (p<0.05) but not (p>0.05). Conclusion: rate control high I/I irrespective treatment group. Overall better prognosis observed 40mg compared 25mg polymorphisms.

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ACE I/D Polymorphism in Hypertensive Patients of Kashmiri Population

BACKGROUND The angiotensin-converting enzyme (ACE) gene in humans has an insertion-deletion (I/D) polymorphic state in intron 16 on chromosome 17q23. This polymorphism has been widely investigated in different diseases. In this study we aimed to investigate the ACE I/D genotype frequency in hypertensive cases in Kashmiri population. MATERIALS AND METHODS We designed a case control study, wher...

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ژورنال

عنوان ژورنال: Journal of Medical and Scientific Research

سال: 2023

ISSN: ['2321-1326', '2394-112X']

DOI: https://doi.org/10.17727/jmsr.2023/11-5